T cell activation can be driven by antibodies
T cell activation can be driven by antibodies
T cell activation can be driven by antibodies
- Our recent work has shown that antibodies can stimulate CD8 T cell activation via the intracellular antibody receptor TRIM21 to enhance MHC class I presentation.
- Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity. Caddy S, Vaysburd M, Papa G, Wing M, O‘Connell K, Stoycheva D, Foss S, Terje Andersen J, Oxenius A and James LC. EMBO J 2021 Mar 1;40(5):e106228.
- An explainer of this discovery has been published by The Conversation.
Rotavirus and intracellular antibodies
T cell activation can be driven by antibodies
T cell activation can be driven by antibodies
- Rotavirus is a major cause of gastroenteritis in young children and animals. Antibodies are made in response to infection, and we have shown that some of these antibodies can work inside cells to block rotavirus replication.
- Intracellular neutralisation of rotavirus by VP6-specific IgG. Caddy S, Vaysburd M, Wing M, Foss S, Terje Andersen J, O‘Connell K, Mayes K, Higginson K, Iturriza-Gómara M, Desselberger U and James LC. PLoS Pathog. 2020 Aug 4;16(8):e1008732
Back Catalogue
Norovirus
Ebolavirus
Ebolavirus
- Evidence for human norovirus infection of dogs in the UK. Caddy et al, Journal of Clinical Microbiology. 2015 Jun;53(6):1873-83
- Genogroup IV and VI canine noroviruses bind to histo-blood groups antigens. Caddy et al, Journal of Virology 2014 15;88(18):10377-91.
- Serological evidence for multiple strains of canine norovirus in the UK dog population. Caddy et al, PLoS ONE 2013 8:e81596.
Ebolavirus
Ebolavirus
Ebolavirus
Sarah Caddy volunteered in Sierra Leone in 2015 during the Ebola Crisis
Contributing author publications:
- Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic. Nature. 2017 Apr 20;544(7650):309-315
- Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015. Euro Surveill. 2015 Oct 8;20(40)
SARS-CoV-2
Ebolavirus
SARS-CoV-2
Editorials
- Developing a vaccine for covid-19. BMJ 2020;369
- Russian SARS-CoV-2 vaccine. BMJ. 2020;370
Contributing author publications
Editorials
- Developing a vaccine for covid-19. BMJ 2020;369
- Russian SARS-CoV-2 vaccine. BMJ. 2020;370
Contributing author publications
- A functional assay for serum detection of antibodies against SARS-CoV-2 nucleoprotein. EMBO J. 2021 Sep 1;40(17):e108588
- Rapid implementation of real-time SARS-CoV-2 sequencing to investigate healthcare-associated COVID-19 infections. Lancet Infectious Diseases 2020. Nov;20(11):1263-1272.
Hepatitis E virus
Hepatitis E virus
Hepatitis E virus
- First Directly-sequenced Genome from the Serum of a Patient from United Kingdom. Genome Announcements. Sep 2016 15;4(5)
- Detection of serum antibodies to Hepatitis E Virus in dogs in the UK. PLoS One 2015 Jun 15;10(6):e0128703
Astrovirus
Hepatitis E virus
Hepatitis E virus
- Complete genome sequence of canine astrovirus with molecular and epidemiological characterisation of UK strains. Caddy S and Goodfellow, I. Veterinary Microbiology. 2015 May 15;177(1-2):206-13